Agranulocytosis after Imipramine and Meprobamate

Reversible agranulocytosis due to meprobamate.

A 52 year old man admitted to hospital in a toxic state, was found to have agranulocytosis, which recovered when an analgesic containing meprobamate was stopped. The patient was known to have had similar symptoms 9 months previously when the drug was first used, thereby demonstrating an idiosyncratic reaction to meprobamate.

Meprobamate in tetanus.

T H E value of oral meprobamate (syn. Equanil, Miltown, Mepavlon) has been for some months 1st day after admission. In the morning his breathing was rather laboured and mucus collected in his throat. Later he managed investigated in this hospital group, as a compoto swallow this and his breathing improved. He was nent of the premedication for children. An interesting publication has appeared re...

Agranulocytosis

David Healy nervous conditions before and after chlorpromazine and imipramine

Sudden onset agranulocytosis and hepatotoxicity after taking methimazole.

Agranulocytosis is a rare adverse effect of methimazole. The usual duration of treatment prior to the onset of agranulocytosis is approximately 1 to 4 months, and can be as long as 1 year. Agranulocytosis together with hepatotoxicity is an extremely rare idiosyncratic side effect of methimazole treatment. We present an unprecedented case of a Grave's disease patient who showed a strong reaction...